Metabolic urate production is the result of purine catabolism, and increase in uric acid is primarily a manifestation of increase purine catabolism once other causes are excluded. The source of purine synthesis is glucose – 6 – phosphate of HMP shunt pathway, synthesized by glucose – 6 – phosphate dehydrogenase enzyme. But a valid study depicting state of this relationship in hyperuricemia is lacking. Also allupurinol the most widely used drug in hyperuricemia may indirectly effect the enzyme activity of glucose – 6 – phosphate dehydrogenase. So the study was conducted to verify the association of carbohydrate and nucleotide metabolism in state of hyperuricemia and effect of treatment with allupurinol on this relationship. The study very effectively proves this relationship (p<<0.001) and also shows a significant effect (p<<0.001) of allupurinol treatment on the activity of enzyme glucose – 6 – phosphate dehydrogenase.
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